Bioelectric Biodegradable Paving and Sealing

Materials and Methods for Endoluminal Electropolymeric Biodegradable Paving and Sealing



Background: The complications associated with current permanent implants such as coronary stents results from both the biocompatibility of the chosen material and the biocompatibility of the implant architecture, i.e. the inherent design deficiencies in the stenting devices. The stent is a foreign object (not native to the body), it incites an immune response which may cause scar tissue (cell proliferation) to rapidly grow over the stent. In addition, there is a strong tendency for clots to form at the site where the stent damages the arterial wall. Lastly, the size and/or structure of the stent may give rise to mechanical stability problems as the stent is much stiffer than the surrounding arteries. Therefore, there is a need in the current medical industry to provide materials and methods for forming smart biomedical implants on endoluminal surfaces without the need for invasive medical procedures, and which have the potential to biodegrade over the lifetime of the implant.

Invention: This invention seeks to address all of these problems, while also providing an integrated electric component so the implant can locally monitor and/or modify the function of an organ or organ component.

Application: A device for electropolymeric paving has been developed. This device includes a biocompatible implantable degradable polymeric material having integrated electrical properties useful for sensing or detecting one or more analytes, signals or conditions, transmitting or generating a signal, or releasing a therapeutic, prophylactic or diagnostic agent.

Advantages: This invention has been demonstrated to be superior to the state-of-the-art in (a) theory, (b) simulations, and © using real data. The inventors simulation results show orders of magnitude in improvement, as compared to traditional methods. Real results from test data closely replicate the performance of our simulations.

• Polymeric composition will reduce the risk of clotting at the site of the stent;

• Greatly reduced risk of scaring as the stent will not trigger an immune response;

• Method can be optimized to the imaged material or tissue of interest; ePEPS procedure provides for in situ formation of biologically compatible smart implants capable of altering, retarding, enhancing, or monitoring an organ component, an organ, or a physiological system.